Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks

Glycoprotein VI is a platelet-specific collagen receptor critical for in vivo formation of arterial thrombosis. It is also considered as an attractive target for the development of anti-thrombotic drugs because blocking glycoprotein (GP)VI inhibits platelet aggregation without inducing detrimental e...

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Publicado en:MAbs
Main Authors: Lebozec, Kristell, Jandrot-Perrus, Martine, Avenard, Gilles, Favre-Bulle, Olivier, Billiald, Philippe
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540112/
https://ncbi.nlm.nih.gov/pubmed/28598281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1336592
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