HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies

This study was designed to determine the in vitro mechanisms by which the novel silybin derivative, (E)-3-(3-(benzyloxy) phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (HM015k or 15k), produces its anticancer efficacy in ovarian cancer cells. Compound 15k induced apoptosis in ovarian cancer cells in a t...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Amawi, Haneen, Hussein, Noor A., Karthikeyan, Chandrabose, Manivannan, Elangovan, Wisner, Alexander, Williams, Frederick E., Samuel, Temesgen, Trivedi, Piyush, Ashby, Charles R., Tiwari, Amit K.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539246/
https://ncbi.nlm.nih.gov/pubmed/28824426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00498
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