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Predictions of Backbone Dynamics in Intrinsically Disordered Proteins Using De Novo Fragment-Based Protein Structure Predictions

Intrinsically disordaered proteins (IDPs) are a prevalent phenomenon with over 30% of human proteins estimated to have long disordered regions. Computational methods are widely used to study IDPs, however, nearly all treat disorder in a binary fashion, not accounting for the structural heterogeneity...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kosciolek, Tomasz, Buchan, Daniel W. A., Jones, David T.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539115/
https://ncbi.nlm.nih.gov/pubmed/28765603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07156-1
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