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Tumor-targeted pH/redox dual-sensitive unimolecular nanoparticles for efficient siRNA delivery

A unique pH/redox dual-sensitive cationic unimolecular nanoparticle (NP) enabling excellent endosomal/lysosomal escape and efficient siRNA decomplexation inside the target cells was developed for tumor-targeted delivery of siRNA. siRNA was complexed into the cationic core of the unimolecular NP thro...

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Dades bibliogràfiques
Publicat a:J Control Release
Autors principals: Chen, Guojun, Wang, Yuyuan, Xie, Ruosen, Gong, Shaoqin
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538929/
https://ncbi.nlm.nih.gov/pubmed/28159516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.01.042
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