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Acidosis increases the susceptibility of respiratory epithelial cells to Pseudomonas aeruginosa-induced cytotoxicity

Bacterial infection can lead to acidosis of the local microenvironment, which is believed to exacerbate disease pathogenesis; however, the mechanisms by which changes in pH alter disease progression are poorly understood. We test the hypothesis that acidosis enhances respiratory epithelial cell deat...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Torres, Iviana M., Demirdjian, Sally, Vargas, Jennifer, Goodale, Britton C., Berwin, Brent
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538871/
https://ncbi.nlm.nih.gov/pubmed/28385813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00524.2016
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