Looping‐out mechanism for resolution of replicative stress at telomeres

Repetitive DNA is prone to replication fork stalling, which can lead to genome instability. Here, we find that replication fork stalling at telomeres leads to the formation of t‐circle‐tails, a new extrachromosomal structure that consists of circular telomeric DNA with a single‐stranded tail. Struct...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Zhang, Tianpeng, Zhang, Zepeng, Li, Feng, Hu, Qian, Liu, Haiying, Tang, Mengfan, Ma, Wenbin, Huang, Junjiu, Songyang, Zhou, Rong, Yikang, Zhang, Shichuan, Chen, Benjamin PC, Zhao, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538764/
https://ncbi.nlm.nih.gov/pubmed/28615293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643866
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