Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation

Hematopoietic stem cells (HSCs) self-renew in bone marrow niches formed by mesenchymal progenitors and endothelial cells that express the chemokine CXCL12, but whether a separate niche instructs multipotent progenitor (MPP) differentiation remains unclear. Here, we show that MPPs resided in HSC nich...

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Enregistré dans:
Détails bibliographiques
Publié dans:Immunity
Auteurs principaux: Gomes, Ana Cordeiro, Hara, Takahiro, Lim, Vivian Y., Herndler-Brandstetter, Dietmar, Nevius, Erin, Sugiyama, Tatsuki, Tani-ichi, Shizue, Schlenner, Susan, Richie, Ellen, Rodewald, Hans-Reimer, Flavell, Richard A., Nagasawa, Takashi, Ikuta, Koichi, Pereira, João Pedro
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538583/
https://ncbi.nlm.nih.gov/pubmed/27913094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.11.004
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