PRKCI promotes immune suppression in ovarian cancer

A key feature of high-grade serous ovarian carcinoma (HGSOC) is frequent amplification of the 3q26 locus harboring PRKC-ι (PRKCI). Here, we show that PRKCI is also expressed in early fallopian tube lesions, called serous tubal intraepithelial carcinoma. Transgenic mouse studies establish PRKCI as an...

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Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Sarkar, Sharmistha, Bristow, Christopher A., Dey, Prasenjit, Rai, Kunal, Perets, Ruth, Ramirez-Cardenas, Alejandra, Malasi, Shruti, Huang-Hobbs, Emmet, Haemmerle, Monika, Wu, Sherry Y., McGuire, Michael, Protopopov, Alexei, Jiang, Shan, Liu, Joyce F., Hirsch, Michelle S., Chang, Qing, Lazar, Alexander J., Sood, Anil K., Drapkin, Ronny, DePinho, Ronald, Draetta, Giulio, Chin, Lynda
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538434/
https://ncbi.nlm.nih.gov/pubmed/28698296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.296640.117
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