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Induction of Apoptosis and Cell Cycle Arrest by Flavokawain C on HT-29 Human Colon Adenocarcinoma via Enhancement of Reactive Oxygen Species Generation, Upregulation of p21, p27, and GADD153, and Inactivation of Inhibitor of Apoptosis Proteins

Chalcones have been shown to exhibit anti-cancer properties by targeting multiple molecular pathways. It was, therefore, of interest to investigate flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava (Piper methysticum Forst) root extract. The aim of this study was t...

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Bibliografiske detaljer
Udgivet i:Pharmacogn Mag
Main Authors: Phang, Chung-Weng, Karsani, Saiful Anuar, Abd Malek, Sri Nurestri
Format: Artigo
Sprog:Inglês
Udgivet: Medknow Publications & Media Pvt Ltd 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538174/
https://ncbi.nlm.nih.gov/pubmed/28808400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0973-1296.210180
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