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T315I clone selection in a Ph+ all patient under low‐dose ponatinib maintenance

We report here the clinical course of a Ph+ ALL patient who was treated with ponatinib 15 mg/day, as maintenance therapy, and developed a BCR‐ABL T315I mutation leading to ALL relapse. This clonal evolution was reversed, without adverse effects, by increasing ponatinib to 45 mg/day. To our knowledge...

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Podrobná bibliografie
Vydáno v:Clin Case Rep
Hlavní autoři: Noetzli, Jasmine, Gavillet, Mathilde, Masouridi‐Levrat, Stavroula, Duchosal, Michel, Spertini, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538043/
https://ncbi.nlm.nih.gov/pubmed/28781850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ccr3.1032
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