A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy

BACKGROUND: Critical limb ischemia (CLI) is a manifestation of peripheral artery disease (PAD) that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown. We previously discovered two overlapping quantitative trait loci (QTL) in mice, Ls...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: McClung, Joseph M., McCord, Timothy J., Ryan, Terence E., Schmidt, Cameron A., Green, Thomas D., Southerland, Kevin W., Reinardy, Jessica L., Mueller, Sarah B., Venkatraman, Talaignair N., Lascola, Christopher D., Keum, Sehoon, Marchuk, Douglas A., Spangenburg, Espen E., Dokun, Ayotunde, Annex, Brian H., Kontos, Christopher D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537727/
https://ncbi.nlm.nih.gov/pubmed/28442482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024873
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