A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy

BACKGROUND: Critical limb ischemia (CLI) is a manifestation of peripheral artery disease (PAD) that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown. We previously discovered two overlapping quantitative trait loci (QTL) in mice, Ls...

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Publicado en:Circulation
Autores principales: McClung, Joseph M., McCord, Timothy J., Ryan, Terence E., Schmidt, Cameron A., Green, Thomas D., Southerland, Kevin W., Reinardy, Jessica L., Mueller, Sarah B., Venkatraman, Talaignair N., Lascola, Christopher D., Keum, Sehoon, Marchuk, Douglas A., Spangenburg, Espen E., Dokun, Ayotunde, Annex, Brian H., Kontos, Christopher D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537727/
https://ncbi.nlm.nih.gov/pubmed/28442482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024873
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