Dovitinib enhances temozolomide efficacy in glioblastoma cells

The multikinase inhibitor and FDA‐approved drug dovitinib (Dov) crosses the blood–brain barrier and was recently used as single drug application in clinical trials for GB patients with recurrent disease. The Dov‐mediated molecular mechanisms in GB cells are unknown. We used GB patient cells and cell...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Thanasupawat, Thatchawan, Natarajan, Suchitra, Rommel, Amy, Glogowska, Aleksandra, Bergen, Hugo, Krcek, Jerry, Pitz, Marshall, Beiko, Jason, Krawitz, Sherry, Verma, Inder M., Ghavami, Saeid, Klonisch, Thomas, Hombach‐Klonisch, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537714/
https://ncbi.nlm.nih.gov/pubmed/28500786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12076
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