Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression

Autoimmune type 1 diabetes (T1D) is thought to be caused by a defective immune regulation with regulatory T (Treg) cells playing a fundamental role in this process. Tolerance mechanisms depend on tunable responses that are sensitive to minor perturbations in the expression of molecules that can be c...

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Publicado no:Sci Rep
Main Authors: Sebastiani, Guido, Ventriglia, Giuliana, Stabilini, Angela, Socci, Carlo, Morsiani, Cristina, Laurenzi, Andrea, Nigi, Laura, Formichi, Caterina, Mfarrej, Bechara, Petrelli, Alessandra, Fousteri, Georgia, Brusko, Todd M., Dotta, Francesco, Battaglia, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537269/
https://ncbi.nlm.nih.gov/pubmed/28761107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07172-1
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