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Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF

Endothelial cells and Leptin Receptor(+) (LepR(+)) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including Stem Cell Factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bo...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Zhou, Bo O., Yu, Hua, Yue, Rui, Zhao, Zhiyu, Rios, Jonathan J., Naveiras, Olaia, Morrison, Sean J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536858/
https://ncbi.nlm.nih.gov/pubmed/28714970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3570
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