The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast

Mutations in the ribosomal protein Rpl10 (uL16) can be drivers of T-cell acute lymphoblastic leukemia (T-ALL). We previously showed that these T-ALL mutations disrupt late cytoplasmic maturation of the 60S ribosomal subunit, blocking the release of the trans-acting factors Nmd3 and Tif6 in S. cerevi...

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Udgivet i:PLoS Genet
Main Authors: Patchett, Stephanie, Musalgaonkar, Sharmishtha, Malyutin, Andrey G., Johnson, Arlen W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536393/
https://ncbi.nlm.nih.gov/pubmed/28715419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006894
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