TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis

Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 a translational-medical target in rosacea....

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Bibliographic Details
Published in:J Invest Dermatol
Main Authors: Chen, Yong, Moore, Carlene D., Zhang, Jennifer Y., Hall, Russell P., MacLeod, Amanda S., Liedtke, Wolfgang
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536341/
https://ncbi.nlm.nih.gov/pubmed/28340683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.12.013
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