Knockout of the gamma subunit of the AP-1 adaptor complex in the human parasite Trypanosoma cruzi impairs infectivity and differentiation and prevents the maturation and targeting of the major protease cruzipain

The AP-1 Adaptor Complex assists clathrin-coated vesicle assembly in the trans-Golgi network (TGN) of eukaryotic cells. However, the role of AP-1 in the protozoan Trypanosoma cruzi—the Chagas disease parasite—has not been addressed. Here, we studied the function and localization of AP-1 in different...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Moreira, Claudia Maria do Nascimento, Batista, Cassiano Martin, Fernandes, Jessica Chimenes, Kessler, Rafael Luis, Soares, Maurilio José, Fragoso, Stenio Perdigão
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536268/
https://ncbi.nlm.nih.gov/pubmed/28759609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179615
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