Internalization and degradation of peptides of the bombesin family in Swiss 3T3 cells occurs without ligand-induced receptor down-regulation.

The binding of [125I]gastrin releasing peptide ([125I]GRP) to Swiss 3T3 cells at 37 degrees C increases rapidly, reaching a maximum after 30 min and decreasing afterwards. The decrease in cell-associated radioactivity at this temperature is accompanied by extensive degradation of the labelled peptid...

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Pubblicato in:	EMBO J
Autori principali:	Zachary, I, Rozengurt, E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC553623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2822383/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1987.tb02495.x
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