Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Incidence and mortality for sex-unspecific cancers is higher among men and is largely unexplained1,2. Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal haematopoietic cells3,4, but the phenotypic consequences of LOY have been elusive5–10. From analysis of 1153 elderly men, we...

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Опубликовано в: :Nat Genet
Главные авторы: Forsberg, Lars A., Rasi, Chiara, Malmqvist, Niklas, Davies, Hanna, Pasupulati, Saichand, Pakalapati, Geeta, Sandgren, Johanna, de Ståhl, Teresita Diaz, Zaghlool, Ammar, Giedraitis, Vilmantas, Lannfelt, Lars, Score, Joannah, Cross, Nicholas C.P., Absher, Devin, Janson, Eva Tiensuu, Lindgren, Cecilia M., Morris, Andrew P., Ingelsson, Erik, Lind, Lars, Dumanski, Jan P.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536222/
https://ncbi.nlm.nih.gov/pubmed/24777449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2966
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