Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling

CXC chemokine ligand (CXCL)9, CXCL10 and CXCL11 direct chemotaxis of mainly T cells and NK cells through activation of their common CXC chemokine receptor (CXCR)3. They are inactivated upon NH(2)-terminal cleavage by dipeptidyl peptidase IV/CD26. In the present study, we found that different glycosa...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Metzemaekers, Mieke, Mortier, Anneleen, Janssens, Rik, Boff, Daiane, Vanbrabant, Lotte, Lamoen, Nicole, Van Damme, Jo, Teixeira, Mauro M., De Meester, Ingrid, Amaral, Flávio A., Proost, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536003/
https://ncbi.nlm.nih.gov/pubmed/28703769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18071513
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