LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes

Metabolic endotoxemia contributes to low-grade inflammation in obesity, which causes insulin resistance due to the activation of intracellular proinflammatory pathways, such as the c-Jun N-terminal Kinase (JNK) cascade in the hypothalamus and other tissues. However, it remains unclear whether the pr...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Rorato, Rodrigo, Borges, Beatriz de Carvalho, Uchoa, Ernane Torres, Antunes-Rodrigues, José, Elias, Carol Fuzeti, Elias, Lucila Leico Kagohara
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535922/
https://ncbi.nlm.nih.gov/pubmed/28677618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18071431
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