Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA-B27) and light (beta 2-microglobulin) chains of HLA class I antigens.

In man a number of diseases are associated with certain alleles of MHC antigens. The most pronounced example is ankylosing spondylitis, which is strongly associated with HLA-B27. As a first step towards a model system to study the basis of this association, transgenic mice were generated that showed...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Krimpenfort, P, Rudenko, G, Hochstenbach, F, Guessow, D, Berns, A, Ploegh, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1987
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC553540/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3301331/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1987.tb02416.x
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