Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

BACKGROUND: The mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer (CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations...

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Publicat a:Chin J Cancer
Autors principals: Geng, Rong, Tan, Xin, Zuo, Zhixiang, Wu, Jiangxue, Pan, Zhizhong, Shi, Wei, Liu, Ranyi, Yao, Chen, Wang, Gaoyuan, Lin, Jiaxin, Qiu, Lin, Huang, Wenlin, Chen, Shuai
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535279/
https://ncbi.nlm.nih.gov/pubmed/28756770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40880-017-0228-1
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