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Single-molecule Förster resonance energy transfer (FRET) analysis discloses the dynamics of the DNA–topoisomerase II (Top2) interaction in the presence of TOP2-targeting agents
Topoisomerases play crucial roles in DNA replication, transcription, and recombination. For instance, topoisomerase II (Top2) is critically important for resolving DNA tangles during cell division, and as such, it is a broad anticancer drug target. Top2 regulates DNA topology by transiently breaking...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5535033/ https://ncbi.nlm.nih.gov/pubmed/28630044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792861 |
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