A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1–5 in human plasma

Age-related macular degeneration (AMD) is a leading cause of visual loss among older adults. Two variants in the complement factor H (CFH) gene, Y402H and I62V, are strongly associated with risk of AMD. CFH is encoded in Regulator of Complement Activation gene cluster in chromosome 1q32, which inclu...

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Udgivet i:Proteomics
Main Authors: Zhang, Pingbo, Zhu, Min, Geng-Spyropoulos, Minghui, Shardell, Michelle, Gonzalez-Freire, Marta, Gudnason, Vilmundur, Eiriksdottir, Gudny, Schaumberg, Debra, Van Eyk, Jennifer E., Ferrucci, Luigi, Semba, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534329/
https://ncbi.nlm.nih.gov/pubmed/27647805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201600237
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