A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin

One third of type-2 diabetic patients respond poorly to metformin. Despite extensive research, the impact of genetic and non-genetic factors on long-term outcome is unknown. In this study, we combine non-linear mixed effect modeling with computational genetic methodologies to identify predictors of...

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Udgivet i:Clin Pharmacol Ther
Main Authors: Goswami, Srijib, Yee, Sook Wah, Xu, Fei, Sridhar, Sneha B., Mosley, Jonathan JD, Takahashi, Atsushi, Kubo, Michiaki, Maeda, Shiro, Davis, Robert L., Roden, Dan M., Hedderson, Monique M., Giacomini, Kathleen M., Savic, Radojka M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534241/
https://ncbi.nlm.nih.gov/pubmed/27415606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.428
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