Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

BACKGROUND: One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g. the NMDA-receptor antagonist kynurenic acid (KYNA), has been implicated in long-term cognitive dysfunc...

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Detalles Bibliográficos
Publicado en:Malar J
Main Authors: Holmberg, Dag, Franzén-Röhl, Elisabeth, Idro, Richard, Opoka, Robert O., Bangirana, Paul, Sellgren, Carl M., Wickström, Ronny, Färnert, Anna, Schwieler, Lilly, Engberg, Göran, John, Chandy C.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534063/
https://ncbi.nlm.nih.gov/pubmed/28754152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-1954-1
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