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Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Pancreatic Cancer Cells to Oncolytic Vesicular Stomatitis Virus

Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV). Although VSV is effective against a majority of pancreatic ductal adenocarcinoma cell (PDAC) cell lines, some PDAC cell lines are highly resistant to VSV, and the mechanisms of resistance are still unclear. JAK1/2 inhibitors (such...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Felt, Sébastien A., Droby, Gaith N., Grdzelishvili, Valery Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533928/
https://ncbi.nlm.nih.gov/pubmed/28566376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00461-17
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