Pharmacokinetic-Pharmacodynamic Relationship of Erenumab (AMG 334) and Capsaicin-Induced Dermal Blood Flow in Healthy and Migraine Subjects

PURPOSE: Capsaicin-induced dermal blood flow (CIDBF) is a validated biomarker used to evaluate the target engagement of potential calcitonin gene-related peptide-blocking therapeutics for migraine. To characterize the pharmacokinetics (PK) and quantify the inhibitory effects of erenumab (AMG 334) on...

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Vydáno v:Pharm Res
Hlavní autoři: Vu, Thuy, Ma, Peiming, Chen, Jiyun Sunny, de Hoon, Jan, Van Hecken, Anne, Yan, Lucy, Wu, Liviawati Sutjandra, Hamilton, Lisa, Vargas, Gabriel
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533838/
https://ncbi.nlm.nih.gov/pubmed/28593473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2183-6
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