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Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays

Spreading depolarization (SD) is a slow propagating wave of strong depolarization of neural cells, implicated in several neuropathological conditions. The breakdown of brain homeostasis promotes significant hemodynamic and metabolic alterations, which impacts on neuronal function. In this work we ai...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lourenço, Cátia F., Ledo, Ana, Gerhardt, Greg A., Laranjinha, João, Barbosa, Rui M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533760/
https://ncbi.nlm.nih.gov/pubmed/28754993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07119-6
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