Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma

Multidrug resistance (MDR) due to overexpression of P-glycoprotein (P-gp) is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). It has been shown that miR-375 inhibits P-gp expression via inhibition of astrocyte elevated gene-1 (AEG-1) expression in HCC, and induces apopt...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Xue, Huiying, Yu, Zhaoyang, Liu, Yong, Yuan, Weigang, Yang, Tan, You, Jia, He, Xingxing, Lee, Robert J, Li, Lei, Xu, Chuanrui
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533569/
https://ncbi.nlm.nih.gov/pubmed/28769563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S135306
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