Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

During obesity, adipose tissue macrophages (ATM) are increased in concert with local inflammation and insulin resistance. Since the levels of sphingolipid (SLs) in adipose tissue (AT) are altered during obesity we investigated the potential impact of SLs on ATMs. For this, we first analyzed expressi...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Gabriel, Tanit L., Mirzaian, Mina, Hooibrink, Berend, Ottenhoff, Roelof, van Roomen, Cindy, Aerts, Johannes M. F. G., van Eijk, Marco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533446/
https://ncbi.nlm.nih.gov/pubmed/28753653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182075
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