Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

During obesity, adipose tissue macrophages (ATM) are increased in concert with local inflammation and insulin resistance. Since the levels of sphingolipid (SLs) in adipose tissue (AT) are altered during obesity we investigated the potential impact of SLs on ATMs. For this, we first analyzed expressi...

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Publicat a:PLoS One
Autors principals: Gabriel, Tanit L., Mirzaian, Mina, Hooibrink, Berend, Ottenhoff, Roelof, van Roomen, Cindy, Aerts, Johannes M. F. G., van Eijk, Marco
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533446/
https://ncbi.nlm.nih.gov/pubmed/28753653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182075
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