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Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

During obesity, adipose tissue macrophages (ATM) are increased in concert with local inflammation and insulin resistance. Since the levels of sphingolipid (SLs) in adipose tissue (AT) are altered during obesity we investigated the potential impact of SLs on ATMs. For this, we first analyzed expressi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gabriel, Tanit L., Mirzaian, Mina, Hooibrink, Berend, Ottenhoff, Roelof, van Roomen, Cindy, Aerts, Johannes M. F. G., van Eijk, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533446/
https://ncbi.nlm.nih.gov/pubmed/28753653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182075
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