The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson’s disease

BACKGROUND/AIMS: Since the degeneration of the nigrostriatal dopaminergic pathway in Parkinson’s disease (PD) is associated with the inflammation process and decreased levels of cyclic nucleotides, inhibition of up-regulated cyclic nucleotide phosphodiesterases (PDEs) appears to be a promising thera...

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Vydáno v:PLoS One
Hlavní autoři: Schwenkgrub, Joanna, Zaremba, Malgorzata, Joniec-Maciejak, Ilona, Cudna, Agnieszka, Mirowska-Guzel, Dagmara, Kurkowska-Jastrzębska, Iwona
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533435/
https://ncbi.nlm.nih.gov/pubmed/28753652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182019
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