Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering

Both kanamycin A and kanamycin B, antibiotic components produced by Streptomyces kanamyceticus, have medical value. Two different pathways for kanamycin biosynthesis have been reported by two research groups. In this study, to obtain an optimal kanamycin A-producing strain and a kanamycin B-high-yie...

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Bibliographic Details
Published in:PLoS One
Main Authors: Gao, Wenli, Wu, Zheng, Sun, Junyang, Ni, Xianpu, Xia, Huanzhang
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533434/
https://ncbi.nlm.nih.gov/pubmed/28753625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181971
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