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Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering

Both kanamycin A and kanamycin B, antibiotic components produced by Streptomyces kanamyceticus, have medical value. Two different pathways for kanamycin biosynthesis have been reported by two research groups. In this study, to obtain an optimal kanamycin A-producing strain and a kanamycin B-high-yie...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gao, Wenli, Wu, Zheng, Sun, Junyang, Ni, Xianpu, Xia, Huanzhang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533434/
https://ncbi.nlm.nih.gov/pubmed/28753625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181971
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