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Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering

Both kanamycin A and kanamycin B, antibiotic components produced by Streptomyces kanamyceticus, have medical value. Two different pathways for kanamycin biosynthesis have been reported by two research groups. In this study, to obtain an optimal kanamycin A-producing strain and a kanamycin B-high-yie...

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Publicat a:PLoS One
Autors principals: Gao, Wenli, Wu, Zheng, Sun, Junyang, Ni, Xianpu, Xia, Huanzhang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533434/
https://ncbi.nlm.nih.gov/pubmed/28753625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181971
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