Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory

Waddington’s epigenetic landscape, a famous metaphor in developmental biology, depicts how a stem cell progresses from an undifferentiated phenotype to a differentiated one. The concept of “landscape” in the context of dynamical systems theory represents a high-dimensional space, in which each cell...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Jia, Dongya, Jolly, Mohit Kumar, Kulkarni, Prakash, Levine, Herbert
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532606/
https://ncbi.nlm.nih.gov/pubmed/28640191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers9070070
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