Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials

OBJECTIVE: Tofacitinib is an oral, small-molecule Janus kinase inhibitor that is being investigated for IBD. We evaluated the efficacy and safety of tofacitinib for induction and maintenance treatment in patients with moderate-to-severe Crohn's disease (CD). DESIGN: We conducted two randomised,...

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Udgivet i:Gut
Main Authors: Panés, Julian, Sandborn, William J, Schreiber, Stefan, Sands, Bruce E, Vermeire, Séverine, D'Haens, Geert, Panaccione, Remo, Higgins, Peter D R, Colombel, Jean-Frederic, Feagan, Brian G, Chan, Gary, Moscariello, Michele, Wang, Wenjin, Niezychowski, Wojciech, Marren, Amy, Healey, Paul, Maller, Eric
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2017
Fag:
Inflammatory Bowel Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532457/
https://ncbi.nlm.nih.gov/pubmed/28209624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-312735
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