Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice

We previously reported brown adipocytes can proliferate even after differentiation. To test the involvement of mature adipocyte proliferation in cell number control in fat tissue, we generated transgenic (Tg) mice over-expressing cell-cycle inhibitory protein p27 specifically in adipocytes, using th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Okamatsu-Ogura, Yuko, Fukano, Keigo, Tsubota, Ayumi, Nio-Kobayashi, Junko, Nakamura, Kyoko, Morimatsu, Masami, Sakaue, Hiroshi, Saito, Masayuki, Kimura, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532220/
https://ncbi.nlm.nih.gov/pubmed/28751675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07206-8
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