Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1

Formyl peptide receptor 1 (FPR1) mediates bacterial and mitochondrial N-formyl peptides-induced neutrophil activation. Therefore, FPR1 is an important therapeutic target for drugs to treat septic or sterile inflammatory diseases. Honokiol, a major bioactive compound of Magnoliaceae plants, possesses...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Liu, Fu-Chao, Yu, Huang-Ping, Syu, Yu-Ting, Fang, Jia-You, Lin, Chwan-Fwu, Chang, Shih-Hsin, Lee, Yen-Tung, Hwang, Tsong-Long
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532207/
https://ncbi.nlm.nih.gov/pubmed/28751674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07131-w
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