A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models

RATIONALE: Drugs that block fatty acid amide hydrolase (FAAH, which elevates anandamide [AEA]) and drugs which block monoacylglycerol (MAGL, which elevates 2-arachidonyl glycerol [2-AG]) have promise in treating both acute and anticipatory nausea in human patients. OBJECTIVE: This study aims to eval...

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Udgivet i:Psychopharmacology (Berl)
Main Authors: Parker, Linda A., Limebeer, Cheryl L., Rock, Erin M., Sticht, Martin A., Ward, Jordan, Turvey, Greig, Benchama, Othman, Rajarshi, Girija, Wood, JodiAnne T., Alapafuja, Shakiru O., Makriyannis, Alexandros
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531749/
https://ncbi.nlm.nih.gov/pubmed/27048155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-016-4277-y
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