The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration

Caveolin-1 (Cav1), a major Src kinase substrate phosphorylated on tyrosine-14 (Y14), contains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; amino acids 82–101). Here we show, using CSD mutants (F92A/V94A) and membrane-permeable CSD-competing peptides, that Src kinase–depen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Cell
Prif Awduron: Meng, Fanrui, Saxena, Sandeep, Liu, Youtao, Joshi, Bharat, Wong, Timothy H., Shankar, Jay, Foster, Leonard J., Bernatchez, Pascal, Nabi, Ivan R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2017
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531735/
https://ncbi.nlm.nih.gov/pubmed/28592633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-05-0278
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg