Histone deacetylase inhibitors decrease intra-abdominal adhesions with one intraoperative dose by reducing peritoneal fibrin deposition pathways

BACKGROUND: We previously demonstrated that postoperative peritoneal injury and inflammation contribute to adhesiogenesis. Recent evidence suggests that in addition to their role of interfering with the acetylation status of nuclear histone proteins, histone deacetylase inhibitors (HDACIs) including...

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Vydáno v:Surgery
Hlavní autoři: Cassidy, Michael R., Sherburne, Alan C., Sheldon, Holly K., Gainsbury, Melanie L., Heydrick, Stanley, Stucchi, Arthur F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531452/
https://ncbi.nlm.nih.gov/pubmed/24239397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2013.08.018
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