Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response

OBJECTIVE: To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. DESIGN: We set-up a unique animal model of periodontitis in C57Bl/6 female mice by infecting the periodontal tissue with specifi...

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Publicado en:Gut
Autores principales: Blasco-Baque, Vincent, Garidou, Lucile, Pomié, Céline, Escoula, Quentin, Loubieres, Pascale, Le Gall-David, Sandrine, Lemaitre, Mathieu, Nicolas, Simon, Klopp, Pascale, Waget, Aurélie, Azalbert, Vincent, Colom, André, Bonnaure-Mallet, Martine, Kemoun, Philippe, Serino, Matteo, Burcelin, Rémy
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2017
Materias:
Gut Microbiota
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531227/
https://ncbi.nlm.nih.gov/pubmed/26838600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-309897
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