Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype

The biomarker potential of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) for the in vivo characterization of preclinical stages in Alzheimer’s disease has not yet been explored. We measured GABA, glutamate + glutamine (Glx), and N-acetyl-aspartate (NAA) levels by single-voxel MEGA-PRESS...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Riese, Florian, Gietl, Anton, Zölch, Niklaus, Henning, Anke, O’Gorman, Ruth, Kälin, Andrea M., Leh, Sandra E., Buck, Alfred, Warnock, Geoffrey, Edden, Richard A.E., Luechinger, Roger, Hock, Christoph, Kollias, Spyros, Michels, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531169/
https://ncbi.nlm.nih.gov/pubmed/25169676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.07.030
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