Increased Aβ(42)-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

BACKGROUND: The apolipoprotein E ε4 (APOE4) genotype is a prominent late-onset Alzheimer’s disease (AD) risk factor. ApoE4 disrupts memory function in rodents and may contribute to both plaque and tangle formation. METHODS: Coimmunoprecipitation and Western blot detection were used to determine: 1)...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Wang, Hoau-Yan, Trocmé-Thibierge, Caryn, Stucky, Andres, Shah, Sanket M., Kvasic, Jessica, Khan, Amber, Morain, Philippe, Guignot, Isabelle, Bouguen, Eva, Deschet, Karine, Pueyo, Maria, Mocaer, Elisabeth, Ousset, Pierre-Jean, Vellas, Bruno, Kiyasova, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530996/
https://ncbi.nlm.nih.gov/pubmed/28750690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-017-0280-8
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