Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A(2) in a spatial-specific manner

Alzheimer’s disease (AD) is histopathologically characterized by the build-up of fibrillar amyloid beta (Aβ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated Tau. Although amyloid fibrils were originally consider...

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Publicado en:Acta Neuropathol Commun
Autores principales: Palavicini, Juan Pablo, Wang, Chunyan, Chen, Linyuan, Hosang, Kristen, Wang, Jianing, Tomiyama, Takami, Mori, Hiroshi, Han, Xianlin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530945/
https://ncbi.nlm.nih.gov/pubmed/28750656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0460-6
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