AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma

AKT signaling is important for proliferation and survival of tumor cells. The clinical significance of AKT activation in diffuse large B-cell lymphoma (DLBCL) is not well analyzed. Here, we assessed expression of phosphorylated AKT (p-AKT) in 522 DLBCL patients. We found that high levels of p-AKT nu...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Wang, Jinfen, Xu-Monette, Zijun Y., Jabbar, Kausar J., Shen, Qi, Manyam, Ganiraju C., Tzankov, Alexandar, Visco, Carlo, Wang, Jing, Montes-Moreno, Santiago, Dybkær, Karen, Tam, Wayne, Bhagat, Govind, Hsi, Eric D., van Krieken, J. Han, Ponzoni, Maurilio, Ferreri, Andrés J.M., Wang, Shi, Møller, Michael B., Piris, Miguel A., Medeiros, L. Jeffrey, Li, Yong, Pham, Lan V., Young, Ken H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2017
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530910/
https://ncbi.nlm.nih.gov/pubmed/28627414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.04.009
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