Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

Proteins perform their functions in solution but their structures are most frequently studied inside crystals. Here we probe how the crystal packing alters microsecond dynamics, using solid-state NMR measurements and multi-microsecond MD simulations of different crystal forms of ubiquitin. In partic...

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Vydáno v:Nat Commun
Hlavní autoři: Kurauskas, Vilius, Izmailov, Sergei A., Rogacheva, Olga N., Hessel, Audrey, Ayala, Isabel, Woodhouse, Joyce, Shilova, Anastasya, Xue, Yi, Yuwen, Tairan, Coquelle, Nicolas, Colletier, Jacques-Philippe, Skrynnikov, Nikolai R., Schanda, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529581/
https://ncbi.nlm.nih.gov/pubmed/28747759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00165-8
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