Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly

The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Here, we show that all three gene clusters functionally cooperate to provide individual mouse olfactory sensory neurons (OSNs) with the cell surface divers...

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Udgivet i:Science
Main Authors: Mountoufaris, George, Chen, Weisheng V., Hirabayashi, Yusuke, O’Keeffe, Sean, Chevee, Maxime, Nwakeze, Chiamaka L., Polleux, Franck, Maniatis, Tom
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529182/
https://ncbi.nlm.nih.gov/pubmed/28450637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aai8801
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