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Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons
Many chemotherapeutic drugs are differentially effective from one patient to the next. Understanding the causes of this variability is a critical step towards the development of personalized treatments and improvements to existing medications. Here, we investigate sensitivity to a group of anti-neop...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5529024/ https://ncbi.nlm.nih.gov/pubmed/28700616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006891 |
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