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Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy

The term ‘inhibitory checkpoint’ refers to the broad spectrum of co‐receptors expressed by T cells that negatively regulate T cell activation thus playing a crucial role in maintaining peripheral self‐tolerance. Co‐inhibitory receptor ligands are highly expressed by a variety of malignancies allowin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Śledzińska, Anna, Menger, Laurie, Bergerhoff, Katharina, Peggs, Karl S., Quezada, Sergio A.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528732/
https://ncbi.nlm.nih.gov/pubmed/26578451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.10.008
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